Key Responsibilities:

• Identification of highly active and selective regulatory elements for incorporation into candidate gene therapies in vitro and in vivo by leveraging a variety of cell-based models and high throughput sequencing technologies
• Preparing bulk RNAseq and single cell RNAseq datasets from a variety of tissue samples
• Performing high throughput screening of coding sequences to identify variants with desired expression levels
• Providing mentorship for junior associates and contributing to the scientific strategy of the team
• Maintaining up-to-date knowledge of emerging technologies and scientific approaches in the field of gene therapy
• Collaborating with cross-functional teams including bioinformatics, AAV production, and in vivo pharmacology teams to advance programs from discovery to development
• Preparing summaries of data and presenting internally to colleagues and management
• Drafting SOPs, following protocols, diligently documenting experimental data in electronic lab notebooks, and authorizing scientific reports for internal documentation or regulatory submissions
• Leading and contributing to publications and presentations at conferences and/or business meetings.
• Actively supporting a culture of innovation, learning, respect, and trust

Essential Requirement:

• PhD with 2+ years of industry or academia experience in molecular biology, genomics, neuroscience, or related fields.
• Proficiency in vector design, cloning, transfection, cell culture, imaging.
• Hands-on experience with molecular and cell biology techniques, including qPCR/ddPCR, western blot, Fluorescence Activated Cell Sorting (FACS), and RNAseq
• Experience in developing cell-based models using a variety of molecular, biochemical, immunological, and/or imaging-based endpoints
• Proven record of productivity and scientific excellence based on publications, patents, and/or external presentations. 
• Independent and critical thinker, multi-tasker, and problem solver with strong verbal and written communication skills, and a team-first mindset.

Desirable Requirements:

• Direct experience with AAV-based gene therapy in preclinical research is preferred.
• Prior experience with single cell/single nuclei RNAseq is a plus

Novartis Compensation and Benefit Summary: The salary for this position is expected to range between $93,800 and $174,200 per year.

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.